Problem running vb.net project compiled to .net framewok 4

I have  .net framework 4.0.30319 installed in C:\Windows\Microsoft.NET\Framework\v4.0.30319and .net framework 4.0 installed in  C:\Program Files (x86)\Reference Assemblies\Microsoft\Framework\.NETFramework\v4.0in my machine.

I am using Visual Studio 2010.  I compiled my vb.net project with target framwork as .net Framework 4. I have no problem running the compiled project in my manchine. But it can't run in a machine that only has .net framework 4.0 installed inC:\Program Files (x86)\Reference Assemblies\Microsoft\Framework\.NETFramework\v4.0 but without that in C:\Windows\Microsoft.NET\Framework\v4.0.30319.

How to I compile the project to have .net framework 4 refer to the one in  C:\Program Files (x86)\Reference Assemblies\Microsoft\Framework\.NETFramework\v4.0.

Kindly advise.

Thank you.

TS Lim