Support policy for .Net Framework

Hello.

I have found .Net Framework Lifecycle (https://support.microsoft.com/en-us/lifecycle/search/548) specified support end date.

That Document explains .Net Framework 4.5.1 has been not supported. In this part, I have some question.

I have run Application set target framework 4.5.1. In this case, If I upgrade .net framework version of machine (Application's server) can I get MS support? Or I have to upgrade target framework version of application also?

Thanks.